Optimizing Longevity Protocols: The Synergistic Potential of Rapamycin, Acarbose, and Metformin

In the pursuit of extending healthspan, the potential of pharmacological interventions like Rapamycin, Metformin, and Acarbose has garnered significant attention. This research review article analyzes the potential synergistic effects of these drugs, particularly focusing on their combined impact on longevity. As researchers analyze the complex mechanisms underlying Acarbose and Metformin, several questions emerge: Could the strategic coupling of either of these drugs with Rapamycin extend survival by delaying the onset of aging? Is one more effective than the other when it comes to longevity? Considering they both work on glycemic control, is there a reason to take both? This research review explores the distinctive mechanisms of action of Metformin and Acarbose, highlighting both their similarities and differences. It presents scientific evidence supporting their benefits for longevity, particularly when used in conjunction with Rapamycin. Additionally, the discussion will explore why Acarbose might be the preferred choice for most people, while a specific subset may continue to benefit from Metformin. This review aims to provide a comprehensive understanding of how these pharmacological interventions can be optimized and tailored to individual needs, ultimately clarifying these ongoing questions on how to incorporate these molecules into longevity protocols.

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By: Shriya Bakhshi, Daniel Tawfik, Brandon Fell, Kristen Race

Published in healthspan -  Read the full article here

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