Rilmenidine and Rapamycin: Do your research.

Rilmenidine and rapamycin are pharmacological agents gaining attention for their potential to promote longevity by targeting aging-related biological pathways. However, their side effect profiles differ significantly, influencing their suitability for long-term use.  It's important to do your own research and work with your general practitioner or a specialist in the longevity space before taking any medication.

These side effects aren't meant to dissuade people from investigating their own health profile and how your personal longevity potential might benefit from their use, but still we at Turning Back the Years want to be sure you understand there are still potential side effects to be aware of. This is why its important to work with professionals who can guide you through how to use these (or not!) in your daily routine.

Rilmenidine

Rilmenidine, an antihypertensive, is associated with a mild side effect profile due to its selective action on imidazoline receptors. Common side effects include:

  • Fatigue
  • Drowsiness
  • Mild gastrointestinal discomfort

Notably, rilmenidine does not significantly suppress the immune system, making it potentially safer for extended use in humans.

Rapamycin

Rapamycin, an mTOR inhibitor, has a broader impact on cellular pathways but poses significant risks:

  • Immunosuppression, increasing susceptibility to infections
  • Hyperlipidemia, leading to elevated cholesterol and triglyceride levels
  • Mouth ulcers
  • Potential glucose intolerance

While rapamycin’s effects on aging are well-documented in mammals, its side effects necessitate careful monitoring and dose adjustments, particularly in humans.

Comparison and Implications

Rilmenidine offers a safer side effect profile for potential repurposing in longevity therapies, especially for individuals who prioritize immune system integrity. In contrast, rapamycin's potent anti-aging effects make it a valuable candidate, but its risks may limit its application to controlled clinical settings.

Further research is required to optimize the use of both drugs in promoting human healthspan.

Sources:

If you're considering Rilmenidine or Rapamycin for its potential benefits, consulting with a healthcare provider is essential to evaluate its risks and benefits in your specific context.

DISCLAIMER: The views expressed in this blog are solely those of the author, based on their research and understanding and should not be taken as professional advice; the author cannot be held liable for any actions taken based on the information provided.

 

Back to blog